Maybe this helps:We had the same problem with FTDI FT232RL.We found out, that it was a hardware issue of our PCB.
FTDI-Datasheet says about #RESET-Pin: Active low reset pin. This can be used by an external device to reset the FT232R. If not required can be left unconnected, or pulled up to VCC.
RESET-Pin was not required in our application, so we connected it to Vcc via 1k Pull-Up.It seemed that the pull-up of #RESET-Pin caused an undefined start-up of the FT232RL, at least every second converter, we connected to a USB-socket caused a serial-ball-point in the devive manager. We removed the pull-up-resistor at #RESET-Pin, therewith the #RESET-Pin is unconnected. Since then every interface worked proberly and didn't any longer create serial-ball-points in the Windows device manager.